Related Experiment Video
Updated: Apr 19, 2026

In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
Conventional- versus high-dose vancomycin regimen in patients with acute bacterial meningitis: a randomized clinical
Sepideh Elyasi1, Hossein Khalili, Simin Dashti-Khavidaki
1Mashhad University of Medical Sciences, Department of Clinical Pharmacy, Faculty of Pharmacy , Mashhad , Iran.
Objective:
Efficacy of the conventional- versus high-dose vancomycin regimen in patients with acute bacterial meningitis was compared.
Methods:
In a randomized clinical trial 44 patients with acute bacterial meningitis were randomly assigned to the conventional- or high-dose vancomycin groups. Clinical and laboratory parameters were used for evaluation of response to the treatment regimens.
Results:
In the high-dose group, leukocytosis and fever resolved significantly faster than those in the conventional group. Furthermore, the length of hospitalization was shorter and Glasgow Coma Scale at the end of 10th day was significantly lower in the high dose compared to the conventional group. Trend of creatinine clearance changes did not differ significantly between the two groups.
Conclusion:
In comparison to the conventional-dose regimen, the high-dose vancomycin regimen was associated with significantly more favorable clinical response without increase in the incidence of nephrotoxicity in patients with acute bacterial meningitis.
Related Concept Videos
Bacterial Meningitis II: Pathophysiology
Bacterial Meningitis I: Introduction
Viral Meningitis
Acute Pyelonephritis II: Diagnostic Studies and Management
Dosage Interval and Administration Route: Determination Methods
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

