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Acromegaly and aging: a comparative cross-sectional study.
Esra Hatipoglu1, Mehmet Yuruyen2, Ela Keskin1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey.
Elderly individuals with acromegaly show poorer cognitive function and increased malnutrition risk compared to controls. Acromegaly negatively impacts geriatric assessment, affecting daily living activities and cognitive health.
Area of Science:
- Gerontology
- Endocrinology
- Internal Medicine
Background:
- Acromegaly, a condition of excess growth hormone, can affect multiple organ systems.
- Geriatric assessment evaluates cognitive, functional, and nutritional status in older adults.
- The impact of acromegaly on geriatric assessment parameters is not well-defined.
Purpose of the Study:
- To compare geriatric assessment findings in elderly patients with acromegaly against a control group.
- To identify specific areas where acromegaly influences cognitive, functional, and nutritional status in the elderly.
Main Methods:
- A comparative cross-sectional study included 30 elderly patients with acromegaly and 30 controls.
- Cognitive function (MMSE), affective status, ADL/IADL, nutritional status (MNA), body composition, functional mobility (TUG), and handgrip strength were assessed.
Main Results:
- Elderly acromegaly patients had significantly lower MMSE scores and higher dementia prevalence.
- Malnutrition risk (MNA scores) was significantly higher in the acromegaly group.
- Moderate functional impairment (Barthel ADL) was more prevalent in acromegaly patients.
Conclusions:
- Acromegaly is associated with impaired cognitive function and functional mobility in the geriatric population.
- Elderly individuals with acromegaly face an increased risk of malnutrition.
- Geriatric assessment reveals distinct differences in acromegaly patients, highlighting the need for targeted interventions.
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