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Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside
T J Nevill1, T J Benstead, C W McCormick
1Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
American Journal of Hematology
|December 1, 1989
Abstract:
High-dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.