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Quasispecies in population of compositional assemblies.

Renan Gross1, Itzhak Fouxon2, Doron Lancet3

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel. renan.gross@weizmann.ac.il.

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Compositional assemblies exhibit quasispecies dynamics, expanding the model beyond sequence-based entities. This finding supports the graded autocatalysis replication domain (GARD) as a model for prebiotic evolution.

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Area of Science:

  • Origin of life studies
  • Systems chemistry
  • Theoretical biology

Background:

  • The quasispecies model describes error-prone self-replication of information carriers, crucial for understanding biological evolution.
  • Traditionally applied to biopolymers like RNA, the model's relevance to prebiotic chemistry is often explored within an RNA world context.
  • This study investigates quasispecies dynamics in compositional entities, distinct from sequence-based biopolymers.

Purpose of the Study:

  • To explore if compositional entities, distinct from biopolymers, can exhibit quasispecies dynamics.
  • To assess the applicability of the graded autocatalysis replication domain (GARD) model in simulating compositional quasispecies.
  • To determine if GARD simulations align with theoretical predictions of the quasispecies model.

Main Methods:

  • Utilized the chemistry-based graded autocatalysis replication domain (GARD) model to simulate compositional molecular assemblies.
  • Defined compotypes as quasi-stationary states in compositional space, with their center-of-mass analogous to a master sequence.
  • Calculated the quasispecies transition matrix (Q) and growth rate vector (A) from GARD dynamics to derive steady-state distributions.

Main Results:

  • A significant correlation was found between steady-state distributions derived from GARD kinetics and the quasispecies equation for compotype center-of-mass distances.
  • The GARD model demonstrated an error catastrophe when the error rate was modified, mirroring the standard quasispecies model.
  • Increased compositional mutations led to the loss of master-like compositions, further supporting quasispecies behavior.

Conclusions:

  • Compositional assemblies simulated by GARD exhibit key attributes of quasispecies dynamics.
  • This research broadens the scope of the quasispecies model to include non-sequence-based entities.
  • The findings enhance the validity of GARD as a model for prebiotic evolutionary processes.