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Related Concept Videos

Vaccine Production01:23

Vaccine Production

108
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
108

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Related Experiment Video

Updated: Apr 19, 2026

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
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Recent progress in dengue vaccine development.

Jianchun Wei1, Hui Chen, Jing An

  • 1Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.

Virologica Sinica
|December 31, 2014
PubMed
Summary
This summary is machine-generated.

Developing effective dengue virus (DENV) vaccines faces challenges like animal models and antibody-dependent enhancement. This review highlights recent progress in candidate DENV vaccines to combat this growing public health concern.

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Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Dengue virus (DENV) infection poses a significant global health threat, causing classic dengue fever and severe dengue hemorrhagic fever/dengue shock syndrome.
  • Four distinct DENV serotypes exist, complicating vaccine development and treatment strategies.
  • DENV infections are increasingly prevalent in epidemic-prone regions, underscoring the urgent need for effective control measures.

Purpose of the Study:

  • To review and summarize recent advancements in the development of candidate dengue virus vaccines.
  • To provide an overview of the challenges hindering the creation of a licensed DENV vaccine.
  • To highlight promising research directions in dengue vaccine technology.

Main Methods:

  • Literature review of recent scientific investigations and clinical trials on DENV vaccines.
  • Analysis of data pertaining to vaccine efficacy, safety, and immunogenicity.
  • Synthesis of information on challenges such as lack of suitable animal models and antibody-dependent enhancement.

Main Results:

  • Significant progress has been made in developing various candidate DENV vaccines.
  • Several vaccine platforms are under investigation, showing varying degrees of success.
  • Key obstacles like the antibody-dependent enhancement phenomenon continue to be addressed.

Conclusions:

  • Despite challenges, the development of effective dengue virus vaccines is advancing.
  • Continued research and innovation are crucial for overcoming hurdles in DENV vaccine creation.
  • Successful dengue vaccines are essential for controlling the global burden of this disease.