Metal complex of the first-generation quinolone antimicrobial drug nalidixic acid: structure and its biological
Anamika Debnath1, Navin Kumar Mogha, Dhanraj T Masram
1Department of Chemistry, University of Delhi, Delhi, 110007, India.
Abstract:
A novel binuclear squire planar complex of nalidixic acid with Ag(I) metal ion with the formula [Ag(Nal)2] has been synthesized. The synthesized metal complex was characterized using CHN analysis, Fourier-transformed infra-red (FT-IR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), ultra violet-visible (Uv-vis) and single-crystal X-ray diffraction (XRD). The newly synthesized complex shows more advanced antifungal activity compared to the parent quinolone against four fungi, namely Pythium aphanidermatum, Sclerotinia rolfsii, Rhizoctonia solani and Rhizoctonia bataticola.
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