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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Updated: Apr 19, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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Clinical research skills development program in cell-based regenerative medicine.

Ivonne Hernandez Schulman1, Viky Suncion2, Vasileios Karantalis2

  • 1Interdisciplinary Stem Cell Institute and Division of Nephrology and Hypertension, Miller School of Medicine, University of Miami, Miami, Florida, USA ischulman@med.miami.edu.

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Physician education in cell-based therapy is crucial for patient safety and regulatory compliance. Implementing academic fellowship programs in regenerative medicine is essential for advancing this promising field.

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Area of Science:

  • Regenerative Medicine
  • Cell-based Therapies
  • Medical Training

Background:

  • Cell-based therapy shows promise for restoring organ function but lacks adequate physician training.
  • Untrained physicians are increasingly using cell-based therapies for chronic illnesses, raising safety concerns.
  • A gap exists between the rapid growth of regenerative medicine and physician preparedness.

Purpose of the Study:

  • To highlight the need for specialized academic fellowship programs in cell-based regenerative medicine.
  • To describe the implementation of a Clinical Research Skills Development Program.
  • To promote the establishment of further fellowship programs for physician training.

Main Methods:

  • Review of the implementation of a two-year Clinical Research Skills Development Program.
  • Focus on training early-career investigators in cell-based clinical and translational research.
  • Drawing from experiences within the Cardiovascular Cell Therapy Network.

Main Results:

  • The Cardiovascular Cell Therapy Network supported a training program at two centers.
  • The program aimed to equip early-career investigators with essential research skills.
  • The review details the institutional implementation of this training model.

Conclusions:

  • Academic medical fellowship programs are vital for preparing physicians in cell-based therapies.
  • Standardized training is necessary to mitigate patient risks and regulatory conflicts.
  • Further development of such programs will advance the field of regenerative medicine.