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Spectrum of Hemoglobinopathies in West Bengal, India: A CE-HPLC Study on 10407 Subjects

Debasis Mukhopadhyay1, Kaushik Saha2, Moumita Sengupta3

  • 1Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, India ; Thalassemia Control Unit (TCU), Institute of Post Graduate Medical Education and Research, Kolkata, India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|December 31, 2014
PubMed

Insights

This study screened 10,407 individuals for hemoglobinopathies in West Bengal using CE-HPLC. The findings highlight the prevalence of beta-thalassemia trait and HbE carriers, emphasizing the need for population screening.

Area of Science:

  • Medical Genetics
  • Hematology
  • Public Health

Background:

  • Hemoglobinopathies are prevalent genetic blood disorders.
  • Epidemiological identification and population screening are crucial for prevention.
  • Understanding the spectrum of these disorders is vital for public health strategies.

Purpose of the Study:

  • To determine the spectrum of hemoglobinopathies in West Bengal.
  • To evaluate the utility of cation-exchange high-performance liquid chromatography (CE-HPLC) for hemoglobinopathy screening.

Main Methods:

  • A retrospective, single-center, cross-sectional study.
  • Analysis of 10,407 consecutive participants.
  • Screening using cation-exchange high-performance liquid chromatography (CE-HPLC).

Main Results:

  • Out of 10,407 subjects, 85.5% were normal.
  • 5.6% were diagnosed with beta-thalassemia trait (BTT).
  • 5.0% were identified as HbE carriers, with ten additional variants detected.

Conclusions:

  • CE-HPLC is an effective, high-throughput screening tool for hemoglobinopathies.
  • Early detection and management of hemoglobinopathies are feasible.
  • Population screening in West Bengal identified significant prevalence of BTT and HbE carriers.

Keywords:
Haemoglobin A2High performance liquid chromatographyScreeningWest Bengalβ-Thalassemia trait

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