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Updated: Apr 19, 2026
14:06
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
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Case series of precursor B-cell lymphoblastic lymphoma
Jin Yong Kim1, Sang Yong Om1, Su-Jin Shin2
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Blood Research
|December 31, 2014
Summary
Precursor B-cell lymphoblastic lymphoma (B-LBL) is rare but can involve bone marrow, challenging previous assumptions. Intensive chemotherapy showed effectiveness in treating this uncommon Non-Hodgkin lymphoma subtype.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Precursor B-cell lymphoblastic lymphoma (B-LBL) is a rare subtype of Non-Hodgkin lymphoma (NHL).
- B-LBL typically presents with extranodal involvement and spares the bone marrow, distinguishing it from T-cell LBL.
Observation:
- A study of 27 patients with lymphoblastic lymphoma (LBL) identified 3 cases of B-LBL.
- These B-LBL cases presented with bone marrow and extranodal involvement (bone, lung), deviating from the typical presentation.
- Patients generally had good performance status and a low International Prognostic Index.
Findings:
- Bone marrow involvement in B-LBL may be more frequent than previously reported.
- Multiple extranodal sites can be affected in B-LBL.
- Intensive combination chemotherapy resulted in complete or partial responses in all treated patients.
Implications:
- Clinical awareness of potential bone marrow involvement in B-LBL is crucial for accurate diagnosis and staging.
- The findings support the efficacy of intensive chemotherapy regimens for B-LBL.
- Further research into B-LBL pathogenesis and optimal treatment strategies is warranted.
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