Chemerin/chemR23 axis in inflammation onset and resolution
Francesco Mariani1, Luca Roncucci
1Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Via Del Pozzo, 71, 41125, Modena, Italy.
Summary
Chemerin, a protein linked to metabolic issues, plays a key role in inflammation and immunity. Targeting the chemerin/chemR23 pathway shows potential for treating inflammatory diseases and cancers.
Area of Science:
- Biochemistry
- Immunology
- Endocrinology
Background:
- Chemerin is an adipokine associated with obesity, insulin resistance, and metabolic syndrome.
- It exists in different forms, influencing inflammation based on protease activity.
- Chemerin interacts with the chemR23 receptor on immune cells, affecting chemotaxis and activation.
Purpose of the Study:
- To review the multifaceted roles of the chemerin/chemR23 axis.
- To highlight its involvement in various physiological and pathological processes.
- To explore its therapeutic potential in diverse diseases.
Main Methods:
- Literature review of studies on chemerin and its receptor chemR23.
- Analysis of the involvement of the chemerin/chemR23 axis in different organs and systems.
- Synthesis of information regarding its role in inflammation, metabolism, and cancer.
Main Results:
- The chemerin/chemR23 axis is implicated in lung, skin, cardiovascular, reproductive, and digestive system disorders.
- It influences both the development of inflammatory diseases and the resolution of inflammation.
- Evidence suggests its role in cancerogenesis across multiple organs.
Conclusions:
- The chemerin/chemR23 pathway is a critical regulator of immune responses and metabolic homeostasis.
- Modulating this axis offers promising therapeutic strategies for inflammatory conditions and cancers.
- Further research into chemerin-derived peptides could lead to novel treatments.
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