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Updated: Apr 19, 2026

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
Published on: June 21, 2024
Soluble ligands and their receptors in human embryo development and implantation
George A Thouas1, Francisco Dominguez, Mark P Green
1Reproductive Biology and Assisted Conception Laboratory (G.A.T., M.P.G., D.K.G.), School of Biosciences, The University of Melbourne, Melbourne, Victoria, Australia 3010; Fundación Instituto Valenciano de Infertilidad (F.D., F.V., C.S.), Department of Obstetrics and Gynecology, University of Valencia, 46010, Valencia, Spain; La Fundación para la Investigación del Hospital Clínico de la Comunidad Valenciana Health Research Institute (F.D., F.V., C.S.), 46010 Valencia, Spain; and Department of Obstetrics and Gynecology (C.S.), Stanford University, Stanford, California 90095.
Abstract:
Extensive evidence suggests that soluble ligands and their receptors mediate human preimplantation embryo development and implantation. Progress in this complex area has been ongoing since the 1980s, with an ever-increasing list of candidates. This article specifically reviews evidence of soluble ligands and their receptors in the human preimplantation stage embryo and female reproductive tract. The focus will be on candidates produced by the human preimplantation embryo and those eliciting developmental responses in vitro, as well as endometrial factors related to implantation and receptivity. Pathways to clinical translation, including innovative diagnostics and other technologies, are also highlighted, drawing from this collective evidence toward facilitating joint improvements in embryo quality and endometrial receptivity. This strategy could not only benefit clinical outcomes in reproductive medicine but also provide broader insights into the peri-implantation period of human development to improve fetal and neonatal health.
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