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Flavonoids from Symplocos racemosa.

Mila Jung1, Janggyoo Choi2, Hee-Sung Chae3

  • 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. jml333@nate.com.

Molecules (Basel, Switzerland)
|December 31, 2014
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Summary

A new compound, sympracemoside, was discovered in Symplocos racemosa. Some isolated flavonoids demonstrated moderate nitric oxide (NO) production inhibitory effects, suggesting potential anti-inflammatory properties.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Symplocos racemosa is a plant used in traditional medicine.
  • Flavonoids are known for their diverse biological activities.

Purpose of the Study:

  • To isolate and characterize compounds from Symplocos racemosa.
  • To evaluate the anti-inflammatory potential of isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation using Q-TOF mass spectrometry, optical rotation, UV, and NMR spectroscopy.
  • In vitro assessment of nitric oxide (NO) production inhibition.

Main Results:

  • A novel isoflavone glycoside, sympracemoside (1), was identified.
  • Fifteen known flavonoids (2-16) were also isolated and characterized.
  • Compounds 3, 9, and 16 exhibited moderate NO inhibitory activity with IC50 values of 88.2, 42.1, and 74.3 μM, respectively.

Conclusions:

  • Symplocos racemosa is a source of novel and known flavonoids.
  • Certain flavonoids from this plant possess anti-inflammatory properties by inhibiting NO production.