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Intravitreal Adalimumab in Active Noninfectious Uveitis: A Pilot Study.
Rola N Hamam1, Anita W Barikian1, Rafic S Antonios1
1a Department of Ophthalmology , American University of Beirut Medical Center , Beirut , Lebanon and.
Ocular Immunology and Inflammation
|December 31, 2014
Summary
Intravitreal adalimumab (IVA) effectively treated active noninfectious uveitis, improving vision and reducing inflammation and macular edema in most patients over 26 weeks.
Area of Science:
- Ophthalmology
- Immunology
- Pharmacology
Background:
- Noninfectious uveitis is an inflammatory eye condition.
- Current treatments may have limitations or side effects.
Purpose of the Study:
- To assess the short-term effectiveness of intravitreal adalimumab (IVA) for active noninfectious uveitis.
Main Methods:
- Patients received IVA injections at weeks 0, 2, and every 4 weeks for 26 weeks.
- Efficacy was measured by visual acuity, anterior chamber cell counts, vitreous haze, macular edema, and fluorescein angiography scores.
Main Results:
- Significant improvements were observed in visual acuity (≥2 ETDRS lines in 7/12 eyes) and reduction of inflammation (anterior chamber cells, vitreous haze).
- Macular edema resolved completely in 5/8 eyes, and fluorescein angiography scores improved markedly.
- One patient (1 eye) did not respond to treatment.
Conclusions:
- Intravitreal adalimumab (IVA) demonstrated efficacy in controlling inflammation and improving visual outcomes in eyes with active noninfectious uveitis.
- IVA reduced macular edema and enhanced best corrected visual acuity in the majority of treated eyes.
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