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Novel Pharmacotherapies for B-Cell Lymphomas and Leukemias

Michael T Tees1, Lubomir Sokol

  • 1Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

American Journal of Therapeutics
|December 31, 2014
PubMed

Insights

New targeted therapies show promise for treating low-grade B-cell neoplasms. This review assesses novel agents like Bruton tyrosine kinase (Btk) inhibitors and B-cell lymphoma/leukemia-2 (Bcl-2) inhibitors for B-cell malignancies.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Low-grade B-cell neoplasms represent a significant area of hematologic oncology.
  • Recent advancements have led to novel therapeutic strategies targeting these malignancies.

Purpose of the Study:

  • To provide a comprehensive review and assessment of current pharmacotherapies under investigation for B-cell lymphomas and leukemias.
  • To highlight the potential of novel agents in treating B-cell malignancies.

Main Methods:

  • Literature review of recently approved and investigational pharmacotherapeutic agents.
  • Assessment of agents targeting specific molecular pathways and cell regulatory proteins.

Main Results:

  • Several novel agents demonstrate impressive activity against malignant B-cell processes.
  • Inhibitors of Bruton tyrosine kinase (Btk), phosphoinositide 3-kinase (PI3-K), B-cell lymphoma/leukemia-2 (Bcl-2), and histone deacetylases are under investigation.
  • Immunomodulatory agents are also being studied.

Conclusions:

  • Novel pharmacotherapies offer expanded treatment options for B-cell malignancies.
  • Targeted agents hold significant potential for improving patient outcomes in B-cell lymphomas and leukemias.

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