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Application of immunohistochemistry in thyroid pathology
1From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania.
Archives of Pathology & Laboratory Medicine
|December 31, 2014
Summary
Diagnosing follicular-patterned thyroid lesions can be challenging. Immunohistochemistry, using a panel of markers, can improve accuracy when combined with standard methods.
Area of Science:
- Thyroid pathology
- Immunohistochemistry
- Molecular diagnostics
Background:
- Follicular-patterned thyroid lesions pose diagnostic challenges due to subtle, subjective criteria on routine H&E or FNA specimens.
- Advances in molecular profiling and immunohistochemistry offer potential solutions for improved diagnostic accuracy.
Purpose of the Study:
- To review the diagnostic utility of commonly studied immunomarkers in thyroid pathology.
- To assess the literature from 1976-2013 using PubMed.
Main Methods:
- Comprehensive literature review.
- Analysis of authors' research data.
- Incorporation of personal practice experience.
Main Results:
- Immunohistochemistry, when applied as a panel of markers, aids in classifying difficult thyroid lesions.
- Standardized technical and interpretational methods are crucial for effective immunohistochemistry.
Conclusions:
- Immunohistochemistry serves as a valuable adjunct to morphologic assessment in thyroid pathology.
- Accurate classification of thyroid lesions is enhanced through the judicious use of immunomarker panels.
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