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Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review
Reuben Tang1, Ing Ching Tang, Amanda Henry
1Department of Maternal-Fetal medicine, Royal Hospital for Women , Sydney , Australia .
Objective:
This article synthesises evidence for calcium supplementation in preeclampsia prevention.
Methods:
Major databases and trial registries were searched, and comparisons were made against other meta-analyses.
Results:
Calcium supplementation reduced the overall risk of preeclampsia in 10 trials (n = 24 787; risk ratio (RR) 0.62; 95% confidence interval [CI] 0.47-0.81). Its effect was larger in two subgroups: low-baseline calcium intake (RR 0.42 [0.23-0.76]) and increased risk of developing hypertensive disorders (RR 0.36 [0.10-0.98]). This effect was not significant amongst larger studies (RR 0.93 [0.83-1.04]). Funnel plotting suggested possible publication bias.
Conclusion:
Some evidence for calcium supplementation exists, but its utility is limited by the possibility of publication bias and a lack of large trials.
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