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Evolution from double to triple-antimalarial drug combinations.

G Dennis Shanks1, Michael D Edstein2, David Jacobus3

  • 1Australian Army Malaria Institute, Enoggera, QLD 4051, Australia School of Population Health, University of Queensland, Brisbane, Australia dennis.shanks@defence.gov.au.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|January 1, 2015
PubMed
Summary

Triple drug combinations offer enhanced efficacy against drug-resistant malaria and can simplify treatment regimens. Future malaria therapies will likely utilize these triple combinations due to emerging resistance.

Keywords:
Antimalarial drugsChemotherapyCombination drug therapyMalaria

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Area of Science:

  • Malariology
  • Pharmacology
  • Infectious Diseases

Background:

  • Drug combinations are crucial for treating multidrug-resistant malaria and delaying resistance evolution.
  • Current antimalarial treatments primarily use binary combinations, but future needs may require triple drug therapies.

Purpose of the Study:

  • To review past triple drug combinations for malaria.
  • To identify potential challenges and future strategies for triple antimalarial drug combinations.

Main Methods:

  • Literature review of previous triple antimalarial drug combinations.
  • Analysis of advantages and disadvantages of poly-pharmacy in malaria treatment.

Main Results:

  • Triple drug combinations can increase efficacy against resistant strains and simplify treatment regimens.
  • Potential drawbacks include increased costs, regulatory hurdles, and formulation challenges due to drug interactions.

Conclusions:

  • Emerging artemisinin resistance necessitates the development of new triple drug combinations for malaria treatment.
  • Triple drug combinations represent a likely future direction for malaria pharmacotherapy, balancing efficacy with potential challenges.