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Two new lignans from Saururus chinensis and their DGAT inhibitory activity
Na Li1, Zhen-Dong Tuo1, Shi-Zhou Qi1
1College of Pharmacy, Beihua University, Jilin City, Jilin Province 132013, People's Republic of China.
Abstract:
Two new lignans were isolated from Saururus chinensis, along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2, 3, 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 44.3±1.5 to 87.5±1.3μM.
