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Identification of the source of A (H10N8) virus causing human infection

Yifei Xu1, Huabin Cao2, Hongyan Liu2

  • 1College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|January 1, 2015
PubMed

Insights

A novel H10N8 influenza A virus emerged in humans in China. Genetic analysis revealed its origins in live poultry markets, highlighting the need for surveillance to prevent future pandemics.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • A novel H10N8 influenza A virus was identified in human cases in China starting December 2013.
  • The evolutionary pathway of this virus, potentially a reassortant from wild birds and domestic poultry, leading to human infection was unclear.
  • Live poultry markets (LPMs) were suspected as the source for the initial human H10N8 infection.

Purpose of the Study:

  • To investigate the evolutionary origins and market dynamics of the novel H10N8 influenza A virus.
  • To assess the role of live poultry markets in the emergence of H10N8 influenza A virus in humans.
  • To understand the continuous evolution of H10N8 viruses within the LPM environment.

Main Methods:

  • Conducted sporadic surveillance at a live poultry market (LPM) suspected of being the source of infection.
  • Analyzed influenza virus prevalence and genetic components in LPMs over time.
  • Performed serological surveillance to determine the virus's presence throughout the LPM system.

Main Results:

  • Influenza virus prevalence increased in the LPM, with H10N8 viruses becoming predominant.
  • Influenza viruses detected in the LPM up to 8 months before human infection contributed genetic material to the zoonotic H10N8 virus.
  • H10N8 viruses continued to evolve within the LPM after the initial human infection.
  • Serological data indicated the virus was widespread within the Nanchang LPM system.

Conclusions:

  • Live poultry markets serve as a crucial environment for the evolution and emergence of novel influenza viruses like H10N8.
  • Continuous monitoring of influenza viruses in LPMs is essential for early detection and prevention of zoonotic spillover.
  • Reducing the influenza virus burden in LPMs is vital to mitigate the risk of future pandemic influenza emergence.
Keywords:
Avian influenza virusH10N8Human infectionLive poultry market

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