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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Postoperative cognitive dysfunction after liver transplantation.

Paola Aceto¹, Valter Perilli¹, Carlo Lai²

¹Department of Anesthesiology and Intensive Care, "A. Gemelli" Hospital, Rome, Italy.

General Hospital Psychiatry

|January 1, 2015

Summary

This summary is machine-generated.

Postoperative cognitive dysfunction (POCD) affects up to 50% of liver transplant (LT) recipients. Further research is needed to identify factors contributing to POCD and its long-term impact.

Keywords:

Cerebral oxygenation Minimal hepatic encephalopathy Neurocognitive deficits Neuroinflammation

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Area of Science:

Hepatology
Neuroscience
Transplant Surgery

Background:

Postoperative cognitive dysfunction (POCD) is a significant concern following liver transplantation (LT).
POCD involves a decline in cognitive functions like memory and mood, diagnosed via neuropsychological tests.
Assessing POCD prevalence and characteristics post-LT is crucial for patient care.

Purpose of the Study:

To systematically review the prevalence of POCD in liver transplant recipients.
To analyze the symptoms, assessment methods, and timing of POCD evaluation after LT.

Main Methods:

A systematic literature search was conducted in PubMed, MEDLINE, and The Cochrane Library from January 1986 to August 2014.
Inclusion criteria comprised prospective and retrospective studies on adult subjects reporting POCD prevalence or sequelae after LT.

Main Results:

Eighteen studies met the eligibility criteria.
The timing for POCD assessment varied widely, from 0.5 to 32 weeks post-LT.
POCD was found to occur in up to 50% of liver transplant recipients.

Conclusions:

Future research should focus on identifying preoperative and intraoperative factors linked to POCD.
Developing strategies to mitigate POCD is essential to reduce this disabling condition.
The long-term outcomes associated with POCD require further investigation.