[Affective disorders: endocrine and metabolic comorbidities]
M Cermolacce1, R Belzeaux2, M Adida2
1Pôle universitaire de psychiatrie, CHU Sainte-Marguerite, 13274 Marseille cedex 9, France; Laboratoire de Neurosciences Cognitives, UMR CNRS 6155 & Aix-Marseille Université, Fédération 3C, Marseille, France.
L'Encephale
|January 1, 2015
Summary
Affective disorders are frequently linked with endocrine-metabolic issues, impacting patient health and mortality. Early screening for these comorbidities is crucial for better management and outcomes.
Area of Science:
- Endocrinology
- Psychiatry
- Metabolic Disorders
Background:
- Affective disorders exhibit complex links with endocrine and metabolic conditions.
- These comorbidities can arise independently or be exacerbated by treatments like antipsychotics and lithium.
Purpose of the Study:
- To review frequent endocrine-metabolic comorbidities in patients with affective disorders.
- To explore the impact of these conditions on morbidity and mortality.
Main Methods:
- Systematic review of literature on endocrine-metabolic comorbidities.
- Examination of metabolic syndrome, glycemic disturbances, obesity, and thyroid disorders.
- Analysis of contributing factors: iatrogenic effects, lifestyle, and physiological vulnerabilities.
Main Results:
- Endocrine-metabolic comorbidities significantly increase cardiovascular risk factors.
- Prevalence is influenced by sex, age, and history of depressive episodes.
- Undertreatment of somatic diseases is a concern.
Conclusions:
- Affective disorders and endocrine-metabolic comorbidities have a substantial impact on morbidity and mortality.
- Systematic screening for subclinical disturbances is recommended.
- Management requires addressing medication side effects and underlying vulnerabilities.
Keywords:
Affective disordersBipolar disordersDiabetesDiabèteMajor depressive disorderMetabolic syndromeObesityObésitéSyndrome métaboliqueThyroidThyroïdeTrouble affectif bipolaireTrouble dépressif majeurTroubles affectifsMore Related Videos
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
23.7K
04:19A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
Published on: May 10, 2022
4.7K
Related Concept Videos
01:27Depressive Disorders: Etiology
885
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
885
01:18Depression: Overview
1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
01:27Depressive Disorders: MDD and Dysthymia
1.2K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.2K
01:24Disorders of the Female Reproductive System
4.9K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.9K
01:27Adrenal Gland Disorders
4.2K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
4.2K
01:27Hyperthyroidism II: Pathophysiology
6
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
6