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[Affective disorders and eating disorders].

Eric Fakra1, R Belzeaux2, J M Azorin2

  • 1Pôle Universitaire de Psychiatrie, CHU Saint-Etienne. - 5 chemin de la Marendière.42055 St Etienne cedex 2, France.

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Summary
This summary is machine-generated.

Affective and eating disorders frequently co-occur, often due to psychotropic medications. This comorbidity worsens prognosis and necessitates careful therapeutic consideration for mood disorders.

Keywords:
AntipsychoticsAntipsychotiquesBipolar disordersMood stabilizersPrise de poidsThymorégulateursTroubles bipolairesWeight gain

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Context:

  • Epidemiologic studies reveal a high comorbidity rate between affective disorders and eating disorders.
  • Patients with one disorder exhibit a significantly higher incidence of the other compared to the general population.
  • This co-occurrence complicates diagnosis and treatment, impacting patient outcomes.

Purpose:

  • To explore potential causes for the frequent co-occurrence of affective and eating disorders.
  • To review the iatrogenic effects of psychotropic medications on eating behaviors.
  • To examine shared semiological characteristics and potential pathophysiological links.
  • To assess the efficacy of psychotropic drugs used in affective disorders for treating comorbid eating disorders.

Summary:

  • Psychotropic medications, particularly mood stabilizers, can induce weight gain and alter eating behaviors, contributing to comorbidity.
  • Shared clinical features between affective and eating disorders may indicate underlying common pathophysiological mechanisms, though genetic evidence is limited.
  • Comorbidity is associated with more severe affective disorders, earlier onset, increased mood episodes, and higher suicidality.

Impact:

  • Understanding the interplay between these disorders and medication effects is crucial for improving patient prognosis.
  • This review aids clinicians in selecting optimal therapeutic strategies for patients with comorbid affective and eating disorders.
  • Highlights the need for further research into shared biological and genetic factors.