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Updated: Apr 19, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Primary gastric small cell carcinoma: a series of seven cases
Takahiro Toyokawa1, Hiroaki Tanaka2, Kazuya Muguruma2
1Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan t-toyokawa@med.osaka-cu.ac.jp.
Aim:
To present a series of seven cases of gastric small cell carcinoma (GSCC) treated surgically and to illustrate the clinicopathological features and clinical course.
Patients And Methods:
Among 1,832 patients with gastric cancer who underwent gastric resection between 1997 and 2012, we reviewed the clinical records of 7 patients with histopathological diagnoses of GSCC.
Results:
No patients had preoperative confirmation of GSCC from endoscopic biopsy. Curative resection (R0) was achieved in 5 patients (71.4%). Two out of the 5 patients with curative resection survived more than four years. Two out of 3 patients who received weekly paclitaxel had progression-free survival of more than 10 months. The median survival time for the whole patient group was 14 months and the 3-year survival rate was 25.0%.
Conclusion:
Curative surgery with adjuvant chemotherapy may be essential to improve the prognosis of GSCC, and weekly paclitaxel chemotherapy may represent a promising chemotherapy for GSCC.
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