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HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene
Bohdan B Khomtchouk1, Derek J Van Booven2, Claes Wahlestedt1
1Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th ST, Miami, 33136 FL USA.
Source Code for Biology and Medicine
|January 1, 2015
Summary
Researchers can now easily create customizable gene expression heatmaps with HeatmapGenerator software. This user-friendly tool simplifies complex data visualization for RNAseq and microarray experiments without requiring extensive programming skills.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomics
Background:
- Graphical visualization of gene expression data using heatmaps is crucial in medical research.
- Heatmaps display quantitative gene expression differences from RNAseq and microarray experiments.
- Creating high-quality, customized heatmaps often demands significant programming expertise.
Purpose of the Study:
- To develop an intuitive, user-friendly software package for generating publication-quality heatmaps.
- To provide researchers with minimal coding experience a tool for customizable heatmap generation.
- To leverage R graphics for high-resolution, visually appealing transcriptomic landscape representations.
Main Methods:
- Developed HeatmapGenerator software using R, C++, and OpenGL for high-performance graphics.
- Created a graphical user interface (GUI) for Windows OS and Mac OS X.
- Designed the software for ease of use, requiring only a preformatted input file and R software.
Main Results:
- HeatmapGenerator offers an intuitive alternative for creating publication-quality heatmaps.
- Users can customize features like color, labels, scaling, and legends without coding knowledge.
- The software simplifies the visualization of transcriptomic data for researchers.
Conclusions:
- HeatmapGenerator is an intuitive and user-friendly software package for creating high-quality, customizable heatmaps.
- The software utilizes R's high-resolution color graphics capabilities and is available for Windows and Mac OS X.
- HeatmapGenerator is released under the GNU General Public License and is publicly available for download.
