Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Next-generation Sequencing03:00

Next-generation Sequencing

102.2K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
102.2K
RNA-seq03:21

RNA-seq

12.7K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
12.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Fentanyl-Responsive Microneedle Patch for Harm Reduction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Role of oral microbiome in cancer immunotherapy.

Seminars in cancer biology·2026
Same author

Expert Consensus on Clinical Application for Digital Full-contour High-translucent/Ultra-translucent Zirconia Restorations.

The Chinese journal of dental research·2026
Same author

[Research Progress and Application Prospects of Saliva-Based Point-of-Care Testing Technologies].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation·2026
Same author

Schwann cell derived extracellular vesicles are multifunctional nanotherapeutic mediators for diabetic oral mucosal wound healing.

Discover nano·2026
Same author

Ca<sub>v</sub>3.2 T-type calcium channels in chronic pain: Structural insights, pharmacological advances and challenges in subtype selectivity.

British journal of pharmacology·2026

Related Experiment Video

Updated: Apr 19, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K

PD_NGSAtlas: a reference database combining next-generation sequencing epigenomic and transcriptomic data for

Zheng Zhao1, Yongsheng Li2, Hong Chen3

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. zhaozheng0503@gmail.com.

BMC Medical Genomics
|January 1, 2015
PubMed
Summary

A new database, PD_NGSAtlas, stores epigenomic and transcriptomic data for psychiatric disorders like schizophrenia and bipolar disorder. This resource aids in understanding disease mechanisms and inheritance patterns.

More Related Videos

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

11.4K
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

10.2K

Related Experiment Videos

Last Updated: Apr 19, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K
A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
09:06

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

11.4K
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

10.2K

Area of Science:

  • Genomics and Bioinformatics
  • Neuroscience
  • Epigenetics

Background:

  • Psychiatric disorders, including schizophrenia (SZ) and bipolar disorder (BP), pose a significant global health challenge.
  • Epigenetic and genetic factors are implicated in these disorders, but their complex inheritance patterns remain unclear.
  • Integrating epigenomic and transcriptomic data is crucial for understanding psychiatric disorder etiology.

Purpose of the Study:

  • To develop PD_NGSAtlas, a database for efficient storage and analysis of epigenomic and transcriptomic data in psychiatric disorders.
  • To provide a quantitative analysis of epigenetic and transcriptional alterations.
  • To facilitate research into the pathophysiology and etiology of psychiatric disorders.

Main Methods:

  • Developed PD_NGSAtlas utilizing next-generation sequencing data (MeDIP-Seq for DNA methylation, RNA-Seq for transcription).
  • Integrated in-house generated and publicly available datasets for SZ, BP, and controls across brain regions and blood.
  • Implemented a flexible query engine, online analysis tools for aberrant events, and a genome browser for data visualization.

Main Results:

  • The PD_NGSAtlas currently houses 43 DNA methylation and 37 transcription profiles.
  • The database includes data from distinct brain regions and peripheral blood samples.
  • Online tools enable identification of aberrantly methylated and expressed events.

Conclusions:

  • PD_NGSAtlas provides a centralized repository for epigenomic and transcriptomic data in psychiatric disorders.
  • The database facilitates detailed investigation into the pathophysiology and etiology of these conditions.
  • PD_NGSAtlas is accessible online for researchers worldwide.