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LHRH increases plasma 7B2 concentration in normal human subjects.

S Natori¹, H Iguchi, M Ohashi

¹Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Endocrinologia Japonica

|June 1, 1989

Summary

Plasma 7B2 levels significantly increased after luteinizing hormone-releasing hormone (LHRH) administration in healthy young adults. This suggests pituitary 7B2 may be released by LHRH, particularly in gonadotrophs.

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Area of Science:

Endocrinology
Neuroendocrinology
Molecular Endocrinology

Background:

The protein 7B2 is found in the pituitary gland.
Its release in response to specific releasing hormones is not fully understood.

Purpose of the Study:

To investigate the effect of luteinizing hormone-releasing hormone (LHRH) and ovine corticotropin-releasing hormone (o-CRH) on plasma 7B2 levels in healthy young subjects.

Main Methods:

Intravenous administration of LHRH to seven young subjects.
Intravenous administration of o-CRH to six young subjects.
Measurement of plasma 7B2 concentrations before and after hormone administration.

Main Results:

Plasma 7B2 concentration significantly increased following LHRH administration (P < 0.01).

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No significant increase in plasma 7B2 was observed after o-CRH administration.

Previous studies showed no increase in plasma 7B2 after thyrotropin-releasing hormone (TRH) and growth hormone-releasing hormone (GHRH) administration.

Conclusions:

Pituitary 7B2 may be present in gonadotrophs.
LHRH appears to be a physiological stimulus for the release of pituitary 7B2.