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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
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Alternative RNA structure-coupled gene regulations in tumorigenesis
1Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan. fcchen@nrhi.org.tw.
International Journal of Molecular Sciences
|January 1, 2015
Summary
Alternative RNA structures (ARSs) regulate cellular phenotypes by altering gene expression, protein diversity, and RNA processing. These ARSs are increasingly linked to tumorigenesis and impact cell fate.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Alternative RNA structures (ARSs) generate diverse protein isoforms and modify regulatory regions like UTRs and introns.
- ARSs influence gene expression through mechanisms such as nonsense-mediated decay and regulation of upstream open reading frames.
Purpose of the Study:
- To review current knowledge on the regulatory roles of ARSs in cellular phenotypes.
- To discuss the implications of ARSs in tumorigenesis and cell fate determination.
Main Methods:
- Literature review of studies investigating ARSs and their regulatory functions.
- Analysis of the impact of ARSs on RNA processing, translation, and gene expression.
Main Results:
- ARSs affect protein diversity, UTRs, intronic regions, and susceptibility to nonsense-mediated decay.
- ARSs modulate microRNA targeting, upstream open reading frames, and intronic microRNA biogenesis.
Conclusions:
- ARSs are critical regulators of cellular phenotypes and cell fate.
- ARS-coupled regulations play significant roles in tumorigenesis, highlighting potential therapeutic targets.
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