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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Notch Signaling Pathway03:14

Notch Signaling Pathway

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
8.8K
Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

8.1K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
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Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.4K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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Related Experiment Video

Updated: Apr 19, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Cell competition: winning out by losing notch.

Maria P Alcolea1, Philip H Jones

  • 1a MRC Cancer Unit; University of Cambridge; Hutchison/MRC Research Center; Cambridge Biomedical Campus ; Cambridge , UK.

Cell Cycle (Georgetown, Tex.)
|January 1, 2015
PubMed
Summary

Somatic mutations can give cells a competitive advantage, leading to clonal expansion in adult tissues. Disruptions in Notch signaling specifically grant

Keywords:
DD, Cell division producing 2 differentiated cellsDN-Maml1, Dominant negative mutant of Mastermind like 1EE, Esophageal EpitheliumEYFP, Enhanced Yellow Fluorescent ProteinGFP, Green Fluorescent proteinNicd, Notch Cytoplasmic DomainPD, Cell division producing one progenitor and one differentiating cellPP, Cell division producing 2 progenitor cellscancercarcinogenesisesophagusfield changeprogenitorsquamousstem cell

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Related Experiment Videos

Last Updated: Apr 19, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Area of Science:

  • Developmental biology
  • Cancer research
  • Cellular mechanisms

Background:

  • Cell competition, where weaker cells are eliminated by fitter neighbors, is crucial in development.
  • Somatic mutations in early cancer development stages allow mutant cells to compete with wild-type cells.
  • Recent research investigates how somatic mutations alter cell competitiveness in adult tissues.

Purpose of the Study:

  • To explore how somatic mutations influence cell competition in adult tissues.
  • To understand the molecular and cellular mechanisms behind altered cell competitiveness.
  • To examine the role of Notch signaling pathway mutations in conferring a 'super competitor' status.

Main Methods:

  • Review of recent studies on cell competition and somatic mutations.
  • Analysis of molecular mechanisms driving cell competitiveness.
  • Focus on squamous epithelia and Notch signaling pathway.

Main Results:

  • Cells with a 'winner' phenotype can form clones, expanding mutant cell fields within normal epithelium.
  • This expansion facilitates the accumulation of genetic alterations, promoting cancer evolution.
  • Mutations disrupting the Notch signaling pathway confer a 'super competitor' advantage in squamous epithelia.

Conclusions:

  • Understanding cell competition dynamics driven by somatic mutations is key to early cancer detection.
  • Notch signaling pathway mutations play a significant role in cancer evolution by promoting cell competitiveness.
  • Further research into these mechanisms can inform cancer prevention and treatment strategies.