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Influence of aggressive nutritional support on growth and development of very low birth weight infants

Y M Xu1, X P Zhu, Z Xiao

  • 1Department of Neonatology, Soochow University Affiliated Children's Hospital, Suzhou, Jiangsu Province, China.

Clinical and Experimental Obstetrics & Gynecology
|January 2, 2015
PubMed

Insights

Aggressive nutritional support for very low birth weight infants (VLBWI) improved growth rates and protein levels. This approach was found to be safe and effective in reducing extrauterine growth restriction during hospitalization.

Area of Science:

  • Neonatalogy
  • Pediatric Nutrition
  • Intensive Care Medicine

Background:

  • Very low birth weight infants (VLBWI) are susceptible to growth issues and complications during hospitalization.
  • Optimizing nutritional support is crucial for improving outcomes in premature neonates.

Purpose of the Study:

  • To evaluate the impact of early aggressive nutritional support on VLBWI during their hospital stay.
  • To compare outcomes between VLBWI receiving aggressive nutritional management and those receiving traditional care.

Main Methods:

  • A comparative study involving 80 VLBWI (gestational age 28-32 weeks, birth weight 1000-1500g) divided into an observation group (aggressive nutrition) and a control group (traditional nutrition).
  • Data collected included nutritional intake, weight gain, jaundice, blood biochemistry, electrolytes, and complications.
  • Infants were monitored for at least two weeks post-admission.

Main Results:

  • The aggressive nutrition group showed significantly higher average growth rates and improved albumin (ALB) and prealbumin (PA) levels.
  • A significant decrease in the incidence of extrauterine growth retardation was observed in the aggressive nutrition group.
  • No significant differences were found in hyperbilirubinemia, liver function, blood lipids, glucose, electrolytes, parenteral nutrition-associated cholestasis (PNAC), or necrotizing enterocolitis (NEC) between the groups.

Conclusions:

  • Early aggressive nutritional management is a safe and effective strategy for VLBWI.
  • This approach can enhance growth and reduce growth restriction in premature infants without increasing the risk of common complications.
Abstract

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