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[Pathogenesis of visceral functions disorder in diffuse peritonitis]
Vestnik Khirurgii Imeni I. I. Grekova
|January 2, 2015
Summary
Diffuse peritonitis causes abdominal sepsis and endotoxicosis, leading to liver insufficiency. Liver rehabilitation, including gut decontamination and corrective infusion therapy, is crucial for treating patients with diffuse peritonitis.
Area of Science:
- Gastroenterology
- Hepatology
- Critical Care Medicine
Context:
- Diffuse peritonitis presents with abdominal sepsis and endotoxicosis.
- Sepsis significantly impacts visceral functions, particularly splanchnic circulation.
- Patients exhibit massive gut translocation of organisms and functional liver insufficiency.
Purpose:
- To investigate the pathogenesis of visceral dysfunction in diffuse peritonitis.
- To highlight the critical role of liver insufficiency, specifically macrophage dysfunction.
- To propose a comprehensive liver rehabilitation strategy for peritonitis patients.
Summary:
- Observed clinical and laboratory signs of abdominal sepsis and endotoxicosis in 194 patients with diffuse peritonitis.
- Pathogenesis involves disturbed splanchnic blood circulation, gut microbial translocation, and liver insufficiency.
- Recommended liver rehabilitation program includes enteral detoxification, intestinal decontamination, and intraportal infusion therapy.
Impact:
- Emphasizes the necessity of integrating liver rehabilitation into diffuse peritonitis treatment standards.
- Suggests preventive measures against enteral intoxication and microbial translocation.
- Highlights the potential of intraportal trans-umbilical infusion for corrective therapy.
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