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Two different forms of endothelin receptors in rat lung
Y Masuda1, H Miyazaki, M Kondoh
1Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
FEBS Letters
|November 6, 1989
Abstract:
We provided evidence for the presence of two distinct types of rat endothelin (ET) receptors having different molecular masses by affinity labelling of rat lung membranes with 125I-ET-1, ET-2 and ET-3 and SDS-PAGE followed by autoradiography. One type, which is 44 kDa has a higher affinity for ET-1 and -2 than ET-3, whereas the other type, which is 32 kDa, preferably interacts with ET-3 rather than ET-1 and -2.