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The increase of mean platelet volume in patients with Alzheimer disease

Emine Rabia Koç1, Ertuğrul Uzar, Yasemin Çirak

  • 1Department of Neurology, Balıkesir University, Turkey. erabiakoc@yahoo.com

Turkish Journal of Medical Sciences
|January 2, 2015
PubMed
Abstract

Insights

Increased mean platelet volume (MPV) in Alzheimer disease (AD) patients suggests platelet dysfunction and potential links to vascular risk factors. This finding may aid in identifying individuals who could benefit from antiplatelet therapy.

Area of Science:

  • Neurology
  • Vascular Biology
  • Hematology

Background:

  • Vascular risk factors significantly influence Alzheimer disease (AD) progression.
  • Mean platelet volume (MPV) reflects platelet function and is linked to vascular inflammation.
  • Elevated MPV is associated with increased risk of vascular events.

Purpose of the Study:

  • To investigate if MPV serves as a marker for vascular damage in AD.
  • To explore the relationship between MPV and other vascular risk factors in AD patients.
  • To assess MPV levels in relation to AD severity.

Main Methods:

  • A study involving 109 AD outpatients and 81 healthy controls.
  • AD diagnosis confirmed using established criteria.
  • Cognitive function assessed via the Mini Mental State Examination (MMSE), categorizing patients into mild (MMSE ≥ 18) and moderate (MMSE < 18) subgroups.

Main Results:

  • Mean platelet volume (MPV) levels were significantly higher in the AD patient group compared to controls.
  • No statistically significant difference in MPV values was observed between the mild and moderate AD subgroups.

Conclusions:

  • Elevated MPV in AD patients may indicate underlying platelet dysfunction and in vivo platelet activation.
  • Platelets may act as a crucial link connecting vascular risk factors and the pathogenesis of AD.
  • MPV assessment could help identify AD patients who might benefit from targeted antiplatelet therapies.

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