Related Experiment Video

Updated: Apr 19, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
09:07

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

14.4K

A nuclear odyssey: fibroblast growth factor-2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system

Benjamin Förthmann1, Claudia Grothe, Peter Claus

  • 1Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

Cellular and Molecular Life Sciences : CMLS
|January 2, 2015
PubMed

Insights

Fibroblast growth factor-2 (FGF-2) isoforms translocate to the nucleus, where they interact with chromatin and proteins. This review explores their structural and functional roles within the nervous system, revealing new insights into FGF-2

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Nuclear localization of growth factors is a known but poorly understood phenomenon.
  • Fibroblast growth factor-2 (FGF-2) exhibits both extracellular and intracellular functions.
  • FGF-2 is expressed in various isoforms from a single mRNA species.

Purpose of the Study:

  • To review the structural and functional aspects of FGF-2 isoforms in the nervous system.
  • To elucidate the nuclear functions of FGF-2 isoforms.
  • To highlight recent discoveries regarding FGF-2's molecular partnerships.

Main Methods:

  • Literature review focusing on FGF-2 nuclear dynamics.
  • Analysis of FGF-2 localization within nuclear bodies (e.g., nucleoli).
  • Examination of FGF-2 interactions with chromatin and other proteins.

Main Results:

  • All FGF-2 isoforms in rodents are imported into the nucleus.
  • FGF-2 exhibits dynamic nuclear behavior, including chromatin binding.
  • New molecular partnerships of FGF-2 isoforms have been identified.

Conclusions:

  • FGF-2's nuclear localization is a significant aspect of its function.
  • Understanding FGF-2 nuclear dynamics and interactions is crucial for its multifaceted roles.
  • Recent findings expand our knowledge of FGF-2's complex functions in the nervous system.

More Related Videos

Analyzing Murine Schwann Cell Development Along Growing Axons09:46

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

12.2K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
11.1K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.9K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.9K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
4.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.5K