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Updated: Apr 19, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Hormonal correlations of premature ejaculation.

Andrea Sansone¹, Francesco Romanelli, Emmanuele A Jannini

¹Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy, andrea.sansone@uniroma1.it.

|January 2, 2015

Summary

Premature ejaculation is a common male sexual dysfunction impacting quality of life. While research on causes and treatments is advancing, the precise endocrine control of ejaculation remains unclear, requiring further study.

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Area of Science:

Reproductive endocrinology
Men's sexual health

Background:

Premature ejaculation (PE) is the most common male sexual dysfunction, affecting up to one-third of men and significantly impairing quality of life.
Increased public interest and reduced delay in seeking medical advice for sexual dysfunctions have led to a greater demand for effective treatments.

Purpose of the Study:

To review the current understanding of the endocrine regulation of ejaculation.
To highlight the need for further research into the hormonal mechanisms underlying ejaculatory disorders.

Main Methods:

Literature review of studies on the causes and treatments of ejaculatory disorders.
Analysis of the established role of endocrine regulation in male reproduction.

Main Results:

While the endocrine control of ejaculation is not fully understood, sex steroid, pituitary, and thyroid hormones are implicated.
Existing research has significantly increased knowledge regarding PE and its management.

Conclusions:

The precise mechanisms of endocrine control over ejaculation require further investigation.
Identifying specific hormonal targets is crucial for developing novel treatments for premature ejaculation.