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Related Concept Videos

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

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Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

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Why measure tumours?

Øystein E Olsen1

  • 1Radiology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK, oeolsen.pedrad@me.com.

Pediatric Radiology
|January 2, 2015
PubMed
Summary
This summary is machine-generated.

Radiologic size measurements in childhood cancers lack scientific rigor, potentially impacting treatment. Standardizing measurements and understanding variability are crucial for accurate pediatric cancer staging.

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Area of Science:

  • Radiology
  • Pediatric Oncology
  • Medical Imaging

Background:

  • Current pediatric cancer staging relies heavily on tumor size measurements.
  • Established radiologic practices, particularly size measurements of childhood solid tumors, are questioned for their scientific justification.

Purpose of the Study:

  • To critically review the scientific basis of size-dependent radiologic practices in pediatric cancer staging.
  • To highlight the need for improved standardization and error estimation in medical imaging for pediatric oncology.

Main Methods:

  • Critical review of staging systems within selected pediatric oncological treatment protocols.
  • Analysis of the role and limitations of size measurements in tumor and lung nodule assessment.

Main Results:

  • Local staging for some pediatric tumors remains size-dependent, influencing treatment intensity.
  • Lack of precise guidance on scan performance, measurement standardization, and accounting for measurement variability in protocols.
  • No evidence supports nodule size as a reliable discriminator between benign and malignant lung nodules.
  • Measurements without error estimation are deemed meaningless, necessitating studies on measurement variability.

Conclusions:

  • Scientific rigor in size measurements for pediatric cancer staging is insufficient.
  • Radiologists must actively contribute to developing standardized, validated, and error-aware staging systems.
  • Addressing measurement variability is essential for accurate staging and appropriate treatment of childhood cancers.