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Calcium infusion for the prevention of ovarian hyperstimulation syndrome: a double-blind randomized controlled trial
Waleed El-Khayat1, Mostafa Elsadek1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt; Middle East Fertility Center, Dokki, Giza, Egypt.
Objective:
To evaluate the role of calcium infusion as a preventive strategy of ovarian hyperstimulation syndrome (OHSS) in women at high risk in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment cycles.
Design:
Double-blinded randomized controlled trial.
Setting:
University hospital department of obstetrics and gynecology and private IVF center.
Patient(S):
Two hundred women at risk to develop OHSS undergoing IVF/ICSI treatment cycle.
Intervention(S):
The intervention group (group 1; n = 100) received intravenous infusion of 10 mL 10% calcium gluconate in 100 mL 0.9% saline solution on the day of ovum pick-up (OPU) and days 1, 2, and 3 after, and the placebo group (group 2; n = 100) received 100 mL 0.9% saline solution on the day of OPU and days 1, 2, and 3 after.
Main Outcome Measure(S):
Incidence of OHSS.
Result(S):
OHSS incidence was significantly higher in the placebo group (group 2) than in the calcium infusion group (group 1): 23 (23%) vs. 7 (7%); moderate OHSS was significantly higher in group 2 than in group 1: 8 (8%) vs. 1 (1%); and severe OHSS was significantly higher in group 2 than in group 1: 4 (4%) vs. 0.
Conclusion(S):
Intravenous calcium infusion effectively reduced the incidence of OHSS development without reduction in the pregnancy rate.
Clinical Trial Registration Number:
NCT01427335.
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