Related Experiment Video
Updated: Apr 19, 2026
08:16
Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
33.9K
The Laugier-Hunziker syndrome
Tahmina Mahmood1, Alan Menter1
1Texas A&M Health Science Center College of Medicine and Baylor University Medical Center at Dallas.
Proceedings (Baylor University. Medical Center)
|January 2, 2015
Summary
Laugier-Hunziker syndrome (LHS) is a benign condition causing oral and nail hyperpigmentation. This case highlights its incidental diagnosis during a routine skin exam, emphasizing its asymptomatic nature.
Area of Science:
- Dermatology
- Genetics
Background:
- Laugier-Hunziker syndrome (LHS) is a rare, benign condition.
- It is characterized by the development of hyperpigmentation.
- This pigmentation typically affects the oral mucosa, lips, and nails.
Observation:
- A 46-year-old Hispanic woman presented with incidental findings of oral and nail hyperpigmentation.
- These pigmentary changes were noted during a routine full body skin examination.
- The patient reported having these asymptomatic changes for years.
Findings:
- A diagnosis of Laugier-Hunziker syndrome (LHS) was established.
- LHS is an acquired condition with characteristic pigmentary skin changes.
- Longitudinal melanonychia is frequently associated with LHS.
Implications:
- This case underscores the importance of recognizing Laugier-Hunziker syndrome during routine dermatological evaluations.
- Understanding the benign and asymptomatic nature of LHS is crucial for appropriate patient management.
- Further research may elucidate the specific genetic or environmental factors contributing to LHS development.
More Related Videos
Related Concept Videos
01:21Huntington Disease l: Introduction
6
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
6
01:22Lysosomal Hydrolases
4.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.8K
01:27Horney's Sociocultural Approach
1.4K
Karen Horney's psychoanalytic theories emphasize the potential for self-realization and the importance of addressing social and cultural, rather than biological, factors in personality development. She challenged traditional Freudian views, particularly Freud's concept of "penis envy," which she argued stemmed from cultural influences rather than inherent biological differences. Horney believed that any sense of inferiority in women was a result of societal conditioning, such as...
1.4K
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
1.2K
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
1.2K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
806
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
806
01:27Esophageal Achalasia
3
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...
3