Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

5.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
5.0K
T Cell Types and Functions01:24

T Cell Types and Functions

3.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.5K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.1K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.1K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

4.6K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.6K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.3K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.3K
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

1
Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous...
1

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>SMARCA4, STK11,</i> and <i>KEAP1</i> co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.

bioRxiv : the preprint server for biology·2026
Same author

"I Don't Trust AI": A Generic Qualitative Analysis of College-Aged Mental Health Clients' Perceptions of Artificial Intelligence Used in Mental Health Counseling.

Behavioral sciences (Basel, Switzerland)·2026
Same author

Plantar Heel Pain Is Not Associated With Fatty Infiltration of the Abductor Digiti Minimi Muscle on Magnetic Resonance Imaging: A Cross-Sectional Observational Study.

Journal of foot and ankle research·2026
Same author

Real World Data Versus Probability Surveys for Estimating Health Conditions at the State Level.

Journal of survey statistics and methodology·2025
Same author

Treating Chronic, Intractable Pain with a Miniaturized Spinal Cord Stimulation System: 1-Year Outcomes from the AUS-nPower Study During the COVID-19 Pandemic.

Journal of pain research·2024
Same author

Is reproductive development adaptively calibrated to early experience? Evidence from a national sample of females.

Developmental psychology·2024

Related Experiment Video

Updated: Apr 19, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.1K

Cell therapy in joint disorders.

Peter D Counsel1, Daniel Bates2, Richard Boyd3

  • 1Imaging at Olympic Park, Melbourne, Victoria, Australia.

Sports Health
|January 2, 2015
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cell (MSC) therapy shows promise for joint disorders, with early human evidence suggesting safety and potential benefits. However, more comparative studies are needed to establish its efficacy against established treatments like autologous chondrocyte implantation.

Keywords:
cartilagecell therapycell transplantationosteoarthritisstem cells

More Related Videos

Magnetic-Activated Cell Sorting Strategies to Isolate and Purify Synovial Fluid-Derived Mesenchymal Stem Cells from a Rabbit Model
10:20

Magnetic-Activated Cell Sorting Strategies to Isolate and Purify Synovial Fluid-Derived Mesenchymal Stem Cells from a Rabbit Model

Published on: August 10, 2018

12.0K
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.9K

Related Experiment Videos

Last Updated: Apr 19, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.1K
Magnetic-Activated Cell Sorting Strategies to Isolate and Purify Synovial Fluid-Derived Mesenchymal Stem Cells from a Rabbit Model
10:20

Magnetic-Activated Cell Sorting Strategies to Isolate and Purify Synovial Fluid-Derived Mesenchymal Stem Cells from a Rabbit Model

Published on: August 10, 2018

12.0K
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.9K

Area of Science:

  • Regenerative Medicine
  • Orthopedic Surgery
  • Biomedical Engineering

Background:

  • Articular cartilage has limited self-repair capabilities.
  • Various treatments, including cell-based therapies, aim to regenerate hyaline cartilage.
  • Mesenchymal stem cells (MSCs) are being investigated for cartilage repair.

Purpose of the Study:

  • To review the current literature on mesenchymal stem cell (MSC) therapy for joint disorders in humans.
  • To evaluate the efficacy and safety of MSC-based treatments compared to existing methods.
  • To identify gaps in the evidence for human application.

Main Methods:

  • A comprehensive literature search was conducted using PubMed up to December 2013.
  • Keywords included 'stem cell,' 'cell therapy,' 'cartilage,' and 'chondrogenic.'
  • Forty-five articles on local MSC therapy for human joint disorders were identified, including nine comparative studies.

Main Results:

  • Two studies comparing MSC treatment to autologous chondrocyte implantation showed similar efficacy.
  • Three studies indicated clinical benefits of intra-articular MSC injection over non-MSC controls in specific surgical contexts.
  • One randomized study found no significant clinical difference at 2 years, but reported better intermediate imaging and histologic outcomes with MSCs.

Conclusions:

  • Mesenchymal stem cell therapies demonstrate safety and efficacy in large animal models for joint disorders.
  • Evidence for human application, especially in comparison to autologous chondrocyte implantation and microfracture, remains limited.
  • Further research is required to solidify the role of MSC therapy in human joint regeneration.