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Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis

Sang-Hoon Kim1, Sang-Heon Kim2, Jae-Hyoung Lee1

  • 1Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.

Allergy, Asthma & Immunology Research
|January 2, 2015
PubMed
Abstract

Insights

Genetic variations in superoxide dismutase 1 (SOD1) may increase the risk of drug-induced liver injury from antituberculosis drugs (ATD). Specifically, the SOD1 rs2070424 polymorphism is linked to ATD-induced hepatitis in Korean individuals.

Area of Science:

  • Pharmacogenomics
  • Hepatology
  • Genetics

Background:

  • Drug-induced liver injury (DILI) is a significant concern in tuberculosis treatment, often necessitating antituberculosis drug (ATD) regimen changes.
  • Antioxidant enzymes are implicated in the pathogenesis of DILI, prompting investigation into their genetic underpinnings.

Purpose of the Study:

  • To investigate the association between polymorphisms in superoxide dismutase genes (SOD1, SOD2, SOD3) and the risk of developing ATD-induced hepatitis.
  • To identify specific genetic variants that may serve as predictive biomarkers for ATD-induced liver injury.

Main Methods:

  • A case-control study compared genotype distributions of single nucleotide polymorphisms (SNPs) in SOD1, SOD2, and SOD3 between patients with ATD-induced hepatitis (n=84) and ATD-tolerant controls (n=237).
  • Specific SNPs analyzed included rs2070424 (SOD1), rs4880 (SOD2), and rs2536512 & rs1799895 (SOD3).

Main Results:

  • The intron SNP rs2070424 in the SOD1 gene was significantly associated with ATD-induced hepatitis (P=0.019, OR=2.26).
  • Individuals with genotypes carrying the minor alleles (GA or GG) at rs2070424 had a higher frequency in the hepatitis group compared to controls.
  • No significant associations were found for the analyzed SNPs in SOD2 and SOD3 genes.

Conclusions:

  • The SOD1 rs2070424 polymorphism is a potential risk factor for developing ATD-induced hepatitis.
  • This genetic variant may help identify individuals at higher risk for liver injury when treated with antituberculosis drugs, particularly in Korean populations.
Keywords:
Antituberculosis drugshepatitispolymorphismsuperoxide dismutase

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