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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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Current strategies and challenges in engineering a bioartificial kidney.

Steven Kim1, William H Fissell1, David H Humes1

  • 1Division of Nephrology, Department of Medicine, University of California, San Francisco.

Frontiers in Bioscience (Elite Edition)
|January 2, 2015
PubMed
Summary

Researchers are developing bioartificial kidneys using cell-based therapies to overcome limitations in current renal replacement therapy. These innovative approaches aim to restore kidney function but require further research for widespread clinical adoption.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nephrology

Background:

  • Renal replacement therapy, including dialysis and kidney transplantation, has significantly improved outcomes for millions with kidney disease.
  • Despite successes, current treatments have limitations affecting patient quality of life and clinical results.

Purpose of the Study:

  • To review the current state-of-the-art in bioartificial kidney development using cell-based therapies.
  • To evaluate techniques aimed at replicating the kidney's complex functions.

Main Methods:

  • Examination of various kidney bioengineering techniques.
  • Assessment of cell-based therapeutic approaches for creating functional bioartificial kidneys.

Main Results:

  • Cell-based therapies show promise in recapitulating kidney functions like solute clearance and fluid homeostasis.
  • Successful preclinical results have been observed in animal models.

Conclusions:

  • Bioartificial kidney development faces challenges including cell sourcing, scaffolding, and immune response.
  • Clinical translation requires further investigation to ensure efficacy and safety in human patients.