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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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Defining dendritic cells.

Barbara U Schraml1, Caetano Reis e Sousa2

  • 1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Trogerstr. 30, 81675 Munich, Germany.

Current Opinion in Immunology
|January 2, 2015
PubMed
Summary

Dendritic cells (DCs), key immune controllers, initiate adaptive immunity. This review explores new ways to identify DCs beyond traditional markers, focusing on their development and differentiation.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial immune cells initiating adaptive immunity.
  • Traditional DC identification relies on morphology, markers, and functions like T cell activation.
  • These characteristics can be unreliable, especially during inflammation or infection.

Purpose of the Study:

  • To review alternative approaches for identifying dendritic cell (DC) lineage.
  • To emphasize recent advancements in understanding DC ontogeny and differentiation.

Main Methods:

  • Literature review of dendritic cell (DC) identification methods.
  • Analysis of recent research on DC ontogeny and differentiation.

Main Results:

  • Traditional DC definitions based on phenotype and function are often insufficient.
  • Emerging insights into DC development offer new avenues for cell attribution.

Conclusions:

  • Rethinking DC identification requires considering ontogeny and differentiation pathways.
  • A deeper understanding of DC development is essential for accurate cell classification.