Related Experiment Video
Updated: Apr 19, 2026
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder
Junya Fujino1, Nobuyuki Yamasaki2, Jun Miyata1
1Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background:
Cognitive behavioral therapy (CBT) is widely used to treat major depressive disorder (MDD). Although improved response prediction could facilitate the development of individualized treatment plans, few studies have investigated whether underlying brain structure is related to CBT response in MDD.
Methods:
Ten MDD patients who received individual CBT were studied in this study. We investigated the relationship between the regional gray matter (GM) volume and subsequent responses to CBT using voxel-based morphometry.
Results:
The degree of improvement in depressive symptoms was positively correlated with GM volume in the caudal portion of the anterior cingulate cortex.
Limitations:
The sample size was small, and the effects of medication on the results could not be excluded.
Conclusions:
Our results, although preliminary, suggest that the anterior cingulate cortex is a key structure whose volume can be used to predict responses to CBT and is thus a potential prognostic marker in MDD.
More Related Videos
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
12:19Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Treatment-Resistant Depression
Published on: April 10, 2026
Related Concept Videos
01:25Cognitive Therapy
01:29The Influence of Cognition on Affect
01:24Rational Emotive Behavior Therapy
01:30Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
01:27Depressive Disorders: MDD and Dysthymia
01:25Beck's Cognitive Therapy
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...