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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
MicroRNAs in human glioblastoma: from bench to beside
Hongxiang Wang1, Tao Xu1, Ying Jiang1
1Department of Neurosurgery, Shanghai Institute of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Abstract:
Glioblastoma (GBM) is the most common and malignant adult primary brain tumor and one of the most lethal types of all cancers. Currently, despite interventional therapy (e.g. multimodal treatments with surgery, radiotherapy and chemotherapy), the overall prognosis for GBM patients remains poor. Thus, it is necessary to understand the molecular pathogenesis of GBM, which provides new insight into modern therapy. As a novel molecule, microRNA (miRNA) contributes to the pathogenesis of various types of tumor, including GBM. So far, miRNA has been shown to function in regulating protein-coding gene expression. This allows miRNAs to have direct function in regulation of various cellular events, including cell proliferation, apoptosis, and differentiation. Great progress has been made in identifying novel tumor-related miRNAs and their potential target genes. In this review, we focus on the most current research in miRNAs and their role in GBM regulation. In addition, we summarize some miRNAs found as biomarkers in GBM and their role in treatment.
Insights
MicroRNAs (miRNAs) play a key role in glioblastoma (GBM) development and progression. Understanding miRNA functions offers new therapeutic strategies for this aggressive brain tumor.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Genetics
Background:
- Glioblastoma (GBM) is a highly aggressive primary brain tumor with a poor prognosis despite current treatments.
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various cancers, including GBM.
Purpose of the Study:
- To review current research on the role of miRNAs in glioblastoma pathogenesis.
- To highlight miRNAs as potential biomarkers and therapeutic targets for GBM.
Main Methods:
- Literature review of studies investigating miRNA function in GBM.
- Analysis of identified tumor-related miRNAs and their target genes.
- Summary of miRNAs as GBM biomarkers and their therapeutic implications.
Main Results:
- miRNAs are crucial regulators of cellular processes involved in GBM, such as proliferation and apoptosis.
- Numerous miRNAs have been identified as potential biomarkers for GBM diagnosis and prognosis.
- miRNAs show promise as targets for novel GBM treatment strategies.
Conclusions:
- miRNAs are integral to GBM molecular pathogenesis and offer new avenues for therapeutic intervention.
- Further research into miRNA biomarkers and therapies could significantly improve GBM patient outcomes.
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