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Published on: January 31, 2018
Poly-ADP-ribosylation signaling during DNA damage repair
Barbara Golia1, Hari R Singh1, Gyula Timinszky1
1Department of Physiological Chemistry, Adolf Butenandt Institute, Ludwig-Maximilians-UniversitätMünchen, Butenandtstr.5, 81377 Munich, Germany.
Abstract:
Poly-ADP-ribosylation is a post-translational modification generated in high amounts by poly-ADP-ribose polymerases (PARPs) in response to cellular stress, especially genotoxic stimuli. DNA damage-induced PARylation significantly changes local chromatin structure and triggers the accumulation of several DNA damage response (DDR) proteins at the DNA lesions. In this review, we will discuss the regulation of chromatin structure and DNA damage repair machineries by DNA damage-induced poly-ADP-ribosylation.
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