Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The C-reactive protein-albumin-lymphocyte index as a novel predictor of long-term mortality after coronary bypass grafting: An international multicenter retrospective study.

Surgery·2026

Same author

In-vivo MRI-based assessment of placental morphology in growth-restricted fetuses.

Placenta·2026

Same author

Seven-year experience (2018-2025) of a hospital-based cardiovascular tissue bank in Israel: operational insights and clinical impact.

Cell and tissue banking·2026

Same author

Progression of bicuspid-related aortopathy in patients undergoing transcatheter aortic valve implantation: Rationale and design of the international, multicenter PROSPERO-TAVI registry.

American heart journal·2026

Same author

Artificial Intelligence-Enhanced Cardiac Point-of-Care Ultrasound: A Prospective Single-Arm Study.

Mayo Clinic proceedings. Digital health·2026

Same author

Coronary Artery Disease in Female Athletes.

JACC. Case reports·2026

Same journal

Regional mechanical differences in hamstring muscles after removal of surrounding connective tissue.

Journal of biomechanics·2026

Same journal

A novel knee joint laxity measurement device in mice.

Journal of biomechanics·2026

Same journal

Influence of iliofemoral ligament laxity on hip joint contact forces during gait.

Journal of biomechanics·2026

Same journal

Associations of sagittal spinal alignment with shear wave velocity, thickness, and echo intensity of muscles attached to the spine and pelvis in healthy women.

Journal of biomechanics·2026

Same journal

The gait lab effect: symmetry restoration strategy after anterior cruciate ligament reconstruction is different in natural environments than the gait laboratory.

Journal of biomechanics·2026

Same journal

Mediolateral trunk control, rather than temporal gait control, is associated with treadmill walking adaptation in healthy older adults.

Journal of biomechanics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Progressive aortic valve calcification: three-dimensional visualization and biomechanical analysis.

Rotem Halevi¹, Ashraf Hamdan², Gil Marom³

¹Faculty of Engineering, Tel-Aviv University, Tel-Aviv 69978, Israel.

Journal of Biomechanics

|January 3, 2015

Summary

This summary is machine-generated.

A new Reverse Calcification Technique (RCT) reconstructs early calcific aortic valve disease (CAVD) stages using CT scans. This method aids in understanding disease progression and mechanical valve performance.

Keywords:

Aortic valve CAVD Calcification Finite element Hounsfield Unit RCT Stenosis

More Related Videos

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

Related Experiment Videos

Last Updated: Apr 19, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

Area of Science:

Biomedical Engineering
Cardiovascular Research
Medical Imaging Analysis

Background:

Calcific aortic valve disease (CAVD) involves progressive calcification of the aortic valve (AV), altering hemodynamics and mechanical function.
Understanding CAVD initiation and progression is crucial for effective patient management.

Purpose of the Study:

To introduce and validate the Reverse Calcification Technique (RCT) for recreating early stages of CAVD.
To analyze the mechanical implications of different calcification patterns using patient-specific data.

Main Methods:

RCT utilizes 3D CT scan data to progressively subtract low-density calcification voxels, reconstructing earlier disease stages.
Finite Element (FE) analysis compared healthy AV mechanics with simulated CAVD configurations.

Main Results:

Four distinct calcification geometries and growth patterns were identified using RCT.
Simulated moderate stenosis reduced orifice area from 2.9cm² to 1.4cm².
Strain magnitude increased significantly (0.24 vs. 0.17) at calcification edges, indicating mechanical stress concentration.

Conclusions:

RCT offers a novel method to visualize and study early CAVD stages and identify potential disease initiation sites.
The technique enables realistic FE mechanical simulations of calcified AVs, aiding in predicting disease progression.