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Related Concept Videos

TSPO-PET/CT Imaging to Detect Infarct Formation in a Mouse Model of Ischemic Stroke09:19

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Source: Chaney, A. M., et.al. PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke. J. Vis. Exp. (2018). This video demonstrates a technique for in vivo imaging of neuroinflammation in a mouse model of ischemic stroke using a TSPO-specific radiotracer. Following injection, the radiotracer binds to TSPO, a protein located on the outer mitochondrial membrane and overexpressed in activated immune cells. A PET/CT scanner detects the...
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Here we will demonstrate the fundamentals of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging using mice. The technique involves injecting a radionuclide into a mouse, imaging the animal after it is distributed throughout the body, and then reconstructing the produced images to create a volumetric dataset. This can...
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Provided here is a practical tutorial for an open-access, standardized image processing pipeline for the purpose of lesion-symptom mapping. A step-by-step walkthrough is provided for each processing step, from manual infarct segmentation on CT/MRI to subsequent registration to standard space, along with practical recommendations and illustrations with exemplary...
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Here, we present a protocol to develop the computerized adaptive testing system of the functional assessment of stroke (CAT-FAS). The CAT-FAS can simultaneously assess four functions (two motor functions [upper and lower extremities], postural control, and basic activities of daily living) with sufficient reliability and administrative...
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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
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Related Experiment Video

Updated: Jan 20, 2026

TSPO-PET/CT Imaging to Detect Infarct Formation in a Mouse Model of Ischemic Stroke
09:19

TSPO-PET/CT Imaging to Detect Infarct Formation in a Mouse Model of Ischemic Stroke

Published on: May 28, 2025

509

One-stop-shop stroke imaging with functional CT.

Elizabeth Tong1, Peter Komlosi1, Max Wintermark2

  • 1Neuroradiology Division, Department of Radiology, University of Virginia, Charlottesville, VA, United States.

European Journal of Radiology
|January 3, 2015
PubMed
Summary
This summary is machine-generated.

Advanced neuroimaging offers dynamic, functional insights beyond anatomy. Multimodal computed tomography (CT), including non-contrast CT (NCCT), perfusion CT (PCT), and CT angiography (CTA), provides rapid, comprehensive stroke assessment to guide treatment.

Keywords:
CTCTAMultimodal CTPerfusion CTStroke

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Related Experiment Videos

Last Updated: Jan 20, 2026

TSPO-PET/CT Imaging to Detect Infarct Formation in a Mouse Model of Ischemic Stroke
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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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Area of Science:

  • Radiology
  • Neurology
  • Medical Imaging

Background:

  • Traditional neuroimaging primarily focused on anatomical details.
  • Recent advancements have shifted focus towards dynamic, physiological, and functional imaging.
  • Neuroimaging now plays a crucial role in guiding clinical decisions, not just diagnosis.

Purpose of the Study:

  • To review the indications and utility of multimodal functional CT in acute stroke imaging.
  • To highlight the integration of various CT modalities for comprehensive stroke evaluation.
  • To emphasize the role of advanced imaging in guiding treatment and follow-up.

Main Methods:

  • Review of non-contrast CT (NCCT) for initial stroke detection.
  • Discussion of perfusion CT (PCT) for assessing tissue viability and perfusion deficits.
  • Explanation of CT angiography (CTA) for evaluating cerebrovascular anatomy and identifying occlusions.

Main Results:

  • Multimodal functional CT, encompassing NCCT, PCT, and CTA, offers a unified approach to acute stroke imaging.
  • Each modality provides distinct yet complementary information crucial for stroke management.
  • Integration of imaging findings with clinical data optimizes treatment strategies.

Conclusions:

  • Multimodal functional CT is an efficient tool for rapid and comprehensive acute stroke assessment.
  • Combining NCCT, PCT, and CTA findings aids in timely and effective clinical decision-making.
  • Advanced neuroimaging techniques are essential for modern stroke care, influencing treatment and follow-up.