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AATF RNome has the potential to define post mortem interval

S Sharma1, Dalbir Singh2, Deepak Kaul3

  • 1Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India; Department of Forensic Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.

Forensic Science International
|January 3, 2015
PubMed

Insights

The study found that the circadian rhythm of the AATF RNome (including AATF mRNA and miR-2909) correlates with the post mortem interval (PMI) in mice. This suggests AATF RNome could be a valuable biomarker in forensic investigations.

Area of Science:

  • Forensic Science
  • Molecular Biology
  • Chronobiology

Background:

  • Circadian rhythms influence fundamental biological processes, including metabolism and behavior.
  • Understanding biological markers that correlate with time since death is crucial for forensic science.

Purpose of the Study:

  • To investigate the potential relationship between the rhythmicity of the AATF RNome and the post mortem interval (PMI).
  • To explore the utility of AATF RNome as a novel biomarker for determining PMI.

Main Methods:

  • Monitoring the circadian rhythm of the AATF RNome, comprising AATF mRNA and its encoded microRNA miR-2909.
  • Analyzing the correlation between AATF RNome rhythmicity and PMI in Balb/c mice.

Main Results:

  • A direct correlation was established between the circadian rhythm of the AATF RNome and the post mortem interval in the studied mice.
  • The findings indicate that AATF RNome exhibits predictable rhythmic patterns relative to time of death.

Conclusions:

  • The circadian rhythm of AATF RNome serves as a reliable indicator of PMI.
  • AATF RNome demonstrates potential as an accurate biomarker for forensic applications, aiding in time of death estimations.
Keywords:
AATF RNomeCircadian pacemakerExpressional stabilityPMI

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