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Updated: Apr 19, 2026

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse
Published on: August 15, 2019
New insights into innate immune restriction of West Nile virus infection
Helen M Lazear1, Michael S Diamond2
1Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Abstract:
West Nile virus (WNV) is an encephalitic flavivirus that has provided a valuable experimental system for studying viral pathogenesis and immunity. Although in vitro approaches and mouse models of infection have identified pattern recognition receptor and interferon pathways that control WNV infection, our appreciation of specific antiviral effectors has been more limited. In this review, we highlight recent advances in our understanding of the host factors that restrict WNV infection in mammals and insects, especially those resulting from large-scale screening approaches.
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