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Updated: Apr 19, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

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TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

Mauricio T Caballero, M Elina Serra, Patricio L Acosta

    The Journal of Clinical Investigation
    |January 3, 2015
    PubMed
    Summary

    Respiratory Syncytial Virus (RSV) disease severity in infants is influenced by Toll-like receptor 4 (TLR4) genotype and lipopolysaccharide (LPS) exposure. A high IL-4/IFN-γ ratio indicates severe RSV infection and Th2 polarization.

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