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Updated: Apr 19, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism
Asta Tvarijonaviciute1, Marco Caldin2, Silvia Martinez-Subiela3
1Departament de Medicina i Cirugia Animals, Universidad Autónoma de Barcelona, Barcelona, Spain.
Abstract:
The aim of this study was to evaluate serum activities of paraoxonase 1 (PON1) using three substrates; (1) 4-nitrophenylacetate (PON1n), (2) phenylacetate (PON1p), and (3) 5-thiobutyl butyrolactonase (PON1t), and butyrylcholinesterase (BChE) in dogs with hyperadrenocorticism (HAC). Serum activities of PON1 and BChE were higher in dogs with HAC than healthy dogs. There were strong positive correlations between PON1 activity measured with the three different substrates. This study demonstrated increased serum PON1 and BChE activities in dogs with HAC that could be attributed to the direct effect of glucocorticoids and lipid mobilisation.
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